Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10488946 | 1.00 | GAA (1.00) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL10488607 | 1.00 | GAA (1.00) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL1991458 | 0.98 | GAA (0.95) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL5098857 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL27472901 | 0.85 | — | — | |
| SCHEMBL491492 | 0.85 | ALDH1A1 (1.00) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL11597254 | 0.85 | ALDH1A1 (1.00) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL11842060 | 0.85 | ALDH1A1 (1.00) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL21560406 | 0.80 | ALDH1A1 (0.80) | GAALMNAALDH1A1CYP3A4TP53 | |
| SCHEMBL3075189 | 0.79 | ALDH1A1 (0.70) | GAALMNAALDH1A1CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016111658-A1 | SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY | IYIDOGAN AYSEGUL (TR) | 2016-07-14 | — | — | WO | claimed |
| EP-2827864-B1 | INHIBITION OF MCL-1 AND/OR BFL-1/A1 | DANA FARBER CANCER INST INC (US) | 2020-09-30 | — | — | EP | disclosed |
| EP-2827864-B1 | INHIBITION OF MCL-1 AND/OR BFL-1/A1 | DANA FARBER CANCER INST INC (US) | 2020-09-30 | — | — | EP | disclosed |
| US-9926306-B2 | Inhibition of MCL-1 and/or BFL-1/A1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-9926306-B2 | Inhibition of MCL-1 and/or BFL-1/A1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| WO-2016111658-A1 | SYNTHESIS OF THIOSEMICARBAZONE DERIVATIVES COMPRISING SULPHONAMIDE GROUP WITH POTENTIAL ANTICONVULSANT ACTIVITY | IYIDOGAN AYSEGUL (TR) | 2016-07-14 | — | — | WO | disclosed |
| US-20150051249-A1 | INHIBITION OF MCL-1 AND/OR BFL-1/A1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-19 | — | — | US | disclosed |
| US-20150051249-A1 | INHIBITION OF MCL-1 AND/OR BFL-1/A1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-19 | — | — | US | disclosed |
| EP-2827864-A1 | INHIBITION OF MCL-1 AND/OR BFL-1/A1 | Dana-Farber Cancer Institute, Inc. (US) | 2015-01-28 | — | — | EP | disclosed |
| CN-102532126-B | 2-substituted-4-chloro-5-[5-subtsituted amino-2-(1,3,4-thiadiazole)-sulfydryl]-3(2H)- pyridazinone derivatives, and preparation method and application thereof | UNIV GUIZHOU | 2014-06-18 | — | — | CN | disclosed |
| WO-2002098420-A1 | 4-SUBSTITUTED-1-(ARYLMETHYLIDENE)THIOSEMICARBAZIDE, 4-SUBSTITUTED-1-(ARYLCARBONYL)THIOSEMICARBAZIDE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-12-12 | — | — | WO | disclosed |
| US-4871737-A | 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0315433-A2 | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4826866-A | 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-05-02 | — | — | US | disclosed |
| US-4492793-A | Process for the production of 2-amino-5-mercapto-1,3,4-thiadiazole | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1985-01-08 | — | — | US | disclosed |
| US-4271308-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| US-4120864-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1978-10-17 | — | — | US | disclosed |
| US-4069377-A | Polymerization of ethylenically unsaturated monomers employing secondary-aliphatic α-substituted azoalkanes | PENNWALT CORPORATION | 1978-01-17 | — | — | US | disclosed |
| US-4028344-A | FOAMING AGENTS, FREE RADICAL INITIATORS | PENNWALT CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-4025502-A | POLYMERIZATION CATALYSTS, CURING AGENTS | PENNWALT CORPORATION (US) | 1977-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051249-A1 | INHIBITION OF MCL-1 AND/OR BFL-1/A1 | BCL2L1, MCL1, BCL2A1 | GAA 1744/4885LMNA 319/4885ALDH1A1 2141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.