Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.44 |
| ▸ | MTOR | P42345 | 11/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586110 | 0.86 | TDP1 (0.41) | PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL4730849 | 0.84 | PIK3CA (0.51) | ATRPIK3CAMTORPIK3CGPDCD1 | |
| SCHEMBL4730042 | 0.74 | PIK3CA (0.44) | ATRPIK3CAMTORPIK3CD | |
| SCHEMBL4729180 | 0.74 | PIK3CA (0.42) | ATRPIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL2370376 | 0.73 | MTOR (0.55) | ATRPIK3CAMTORPIK3R1 | |
| SCHEMBL2370380 | 0.73 | MTOR (0.55) | ATRPIK3CAMTORPIK3R1 | |
| SCHEMBL4728823 | 0.72 | KDM4E (0.41) | PIK3CAMTORPIK3CDCYP2C9PIK3CG | |
| SCHEMBL4573462 | 0.71 | TDP1 (0.45) | PIK3CAMTORPIK3CDCYP2C9PIK3CG | |
| SCHEMBL4572918 | 0.70 | PIK3CA (0.41) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL15805552 | 0.69 | MTOR (0.52) | ATRPIK3CAMTORPIK3CDPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032036-A1 | 6-BENZIMIDAZ0LYL-2-M0RPH0LIN0-4- (AZETIDINE, PYRROLIDINE, PIPERIDINE OR AZEPINE) PYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032089-A1 | 4-BENZIMIDAZ0LYL-2-M0RPH0LIN0-6-PIPERIDIN-4-YLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008032033-A1 | 4-BENZIMIDAZOLYL-2-MORPHOLINO-6-PIPERAZINYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |