Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586110 | 0.83 | TDP1 (0.41) | KDM4EL3MBTL1TDP1TSHRHSD17B10 | |
| SCHEMBL1680073 | 0.73 | PIK3CB (0.40) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL4585107 | 0.72 | ATR (0.49) | PIK3CAPIK3CDPIK3CGCYP2C9MTOR | |
| SCHEMBL4573462 | 0.69 | TDP1 (0.45) | KDM4EL3MBTL1TDP1TSHRHSD17B10 | |
| SCHEMBL4730042 | 0.67 | PIK3CA (0.44) | TSHRHSD17B10MAPTPIK3CBPIK3CA | |
| SCHEMBL4798842 | 0.67 | MTOR (0.50) | KDM4EL3MBTL1TDP1HSD17B10LMNA | |
| SCHEMBL4729180 | 0.66 | PIK3CA (0.42) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL4572918 | 0.66 | PIK3CA (0.41) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL920268 | 0.66 | ALDH1A1 (0.34) | — | |
| SCHEMBL3991404 | 0.66 | MAPT (0.51) | L3MBTL1MAPTMEN1KMT2APIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |