Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levotofisopam SCHEMBL5431173 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| Dextofisopam SCHEMBL236796 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| Tofisopam SCHEMBL29832594 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| Dextofisopam SCHEMBL8086913 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| Dextofisopam SCHEMBL29376877 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| Tofisopam SCHEMBL43522 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| Tofisopam SCHEMBL8086894 | 1.00 | KMT2A (1.00) | KMT2APDE4AMEN1CHRM1PDE4D | |
| SCHEMBL5426026 | 0.94 | PDE4A (0.88) | KMT2APDE4AMEN1CHRM1PDE4D | |
| SCHEMBL5424919 | 0.94 | PDE4A (0.88) | KMT2APDE4AMEN1CHRM1PDE4D | |
| SCHEMBL5425481 | 0.94 | PDE4A (0.88) | KMT2APDE4AMEN1CHRM1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567162-A4 | TREATMENT OF IRRITABLE BOWEL SYNDROME AND NONULCER DYSPEPSIA WITH SUBSTITUTED 2,3-BENZODIAZEPINES | VELA ACQUISITION CORP (US) | 2008-04-30 | — | — | EP | disclosed |
| EP-1575521-A4 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | VELA ACQUISITION CORP (US) | 2008-04-30 | — | — | EP | disclosed |
| EP-1575521-A2 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | Vela Pharmaceuticals Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| EP-1567162-A2 | TREATMENT OF IRRITABLE BOWEL SYNDROME AND NONULCER DYSPEPSIA WITH SUBSTITUTED 2,3-BENZODIAZEPINES | Vela Pharmaceuticals Inc. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004073638-A2 | METHOD OF LOWERING BODY TEMPERATURE WITH (S)-2,3-BENZODIAZEPINES | VELA PHARMACEUTICALS, INC. (US) | 2004-09-02 | — | — | WO | disclosed |
| WO-2004069155-A2 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | VELA PHARMACEUTICALS, INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004050616-A2 | TREATMENT OF IRRITABLE BOWEL SYNDROME AND NONULCER DYSPEPSIA WITH SUBSTITUTED 2,3-BENZODIAZEPINES | VELA PHARMACEUTICALS, INC. (US) | 2004-06-17 | — | — | WO | disclosed |