Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 10/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470197 | 0.90 | MEN1 (0.47) | BACE1MAPK8MEN1KMT2ALMNA | |
| SCHEMBL459978 | 0.90 | BACE1 (0.41) | NPY2RBACE1MAPK8REV1LMNA | |
| SCHEMBL12272881 | 0.88 | ATR (0.41) | NPY2RBACE1REV1KMT2ALMNA | |
| SCHEMBL27913497 | 0.87 | NPY2R (0.38) | NPY2RBACE1MAPK8REV1MEN1 | |
| SCHEMBL459977 | 0.87 | NPY2R (0.38) | NPY2RBACE1MAPK8REV1MEN1 | |
| SCHEMBL27913478 | 0.83 | MAPT (0.52) | NPY2RMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL27931713 | 0.82 | NPY2R (0.48) | NPY2RMEN1KMT2AMAPT | |
| SCHEMBL457432 | 0.81 | MEN1 (0.51) | BACE1MAPK8MEN1KMT2ALMNA | |
| SCHEMBL470212 | 0.81 | MEN1 (0.51) | BACE1MAPK8MEN1KMT2ALMNA | |
| SCHEMBL463132 | 0.80 | BACE1 (0.49) | BACE1MAPK8MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201268-B | As the novel piperazine analogue of wide spectrum influenza virus medicine | BRISTOL-MYERS SQUIBB CO. (US) | 2015-08-12 | — | — | CN | disclosed |
| EP-2614052-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | Bristol-Myers Squibb Company (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033736-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |