Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estriol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 5/20 | 0.76 |
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 5/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.76 |
| ▸ | PGR | P06401 | 2/20 | 0.76 |
| ▸ | AR | P10275 | 2/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.76 |
| ▸ | SHBG | P04278 | 1/20 | 0.76 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.76 |
| ▸ | SNCA | P37840 | 1/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.76 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.76 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estriol SCHEMBL345507 | 0.93 | ESR1 (0.83) | ESR1LMNAESR2HIF1APGR | |
| Estriol SCHEMBL6331811 | 0.91 | ESR1 (0.83) | ESR1LMNAESR2HIF1APGR | |
| Estriol SCHEMBL5527393 | 0.91 | ESR1 (0.83) | ESR1LMNAESR2HIF1APGR | |
| Estradiol SCHEMBL7638916 | 0.89 | ESR1 (0.77) | ESR1LMNAESR2HIF1APGR | |
| Estradiol SCHEMBL7186616 | 0.89 | ESR1 (0.77) | ESR1LMNAESR2HIF1APGR | |
| Alfatradiol SCHEMBL22092636 | 0.89 | ESR1 (0.77) | ESR1LMNAESR2HIF1APGR | |
| Estradiol SCHEMBL8001333 | 0.89 | ESR1 (0.77) | ESR1LMNAESR2HIF1APGR | |
| Estradiol SCHEMBL40565 | 0.89 | ESR1 (0.77) | ESR1LMNAESR2HIF1APGR | |
| Estriol SCHEMBL2519922 | 0.88 | ESR1 (0.89) | ESR1LMNAESR2HIF1APGR | |
| Estriol SCHEMBL7989770 | 0.88 | ESR1 (0.89) | ESR1LMNAESR2HIF1APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325235-B | Medical delivery device with low lubrication syringe barrel | W.L.戈尔及同仁股份有限公司 | 2022-02-11 | — | — | CN | disclosed |
| CN-101252936-A | Pharmaceutically acceptable carrier for ophthalmic compositions | NASCENT PHARMACEUTICAL INC (US) | 2008-08-27 | — | — | CN | disclosed |
| EP-1858522-A4 | PHARMACEUTICALLY ACCEPTABLE CARRIER FOR OPHTHALMIC COMPOSITIONS | NASCENT PHARMACEUTICAL INC (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1858522-A1 | PHARMACEUTICALLY ACCEPTABLE CARRIER FOR OPHTHALMIC COMPOSITIONS | Nascent Pharmaceutical, Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| EP-1858523-A1 | COMBINAION THERAPY FOR TOPICAL APPLICATION IN THE TREATMENT OF DRY EYE SYNDROME | Nascent Pharmaceutical, Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| US-20060211660-A1 | Combination therapy for topical application in the treatment of dry eye syndrome | ALTOS VISION LIMITED (GB) | 2006-09-21 | — | — | US | disclosed |
| US-20060210645-A1 | Pharmaceutically acceptable carrier for ophthalmic compositions | ALTOS VISION LIMITED (GB) | 2006-09-21 | — | — | US | disclosed |
| WO-2006094026-A1 | PHARMACEUTICALLY ACCEPTABLE CARRIER FOR OPHTHALMIC COMPOSITIONS | NASCENT PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| WO-2006094028-A1 | COMBINAION THERAPY FOR TOPICAL APPLICATION IN THE TREATMENT OF DRY EYE SYNDROME | NASCENT PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |
| CN-1404394-A | Composition comprising a metal oxide and a metal oxide | STERIX LTD (GB) | 2003-03-19 | — | — | CN | disclosed |
| US-6096733-A | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application | Lubkin, Virginia (US) | 2000-08-01 | — | — | US | disclosed |