Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26495422 | 0.96 | KDM4C (0.51) | GPR84FFAR1FFAR4LMNACAMK2A | |
| SCHEMBL26495489 | 0.94 | GPR84 (0.54) | GPR84FFAR1FFAR4LMNATSHR | |
| SCHEMBL12051225 | 0.94 | GPR84 (0.54) | GPR84FFAR1FFAR4LMNATSHR | |
| SCHEMBL26495622 | 0.94 | GPR84 (0.54) | GPR84FFAR1FFAR4LMNATSHR | |
| SCHEMBL26495389 | 0.93 | KDM4C (0.50) | GPR84FFAR1FFAR4LMNACAMK2A | |
| Stearic Acid SCHEMBL28730472 | 0.90 | GPR84 (0.65) | GPR84FFAR1FFAR4TSHRAKR1B1 | |
| Stearic Acid SCHEMBL27886665 | 0.90 | GPR84 (0.65) | GPR84FFAR1FFAR4TSHRAKR1B1 | |
| SCHEMBL3952397 | 0.88 | KMT2A (0.48) | CAMK2AMEN1KMT2A | |
| SCHEMBL26495428 | 0.86 | GPR84 (0.56) | GPR84FFAR1FFAR4LMNACAMK2A | |
| SCHEMBL26495437 | 0.86 | GPR84 (0.62) | GPR84FFAR1FFAR4LMNACAMK2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1469813-A4 | ADDITIVES AND PRODUCTS INCLUDING OLIGOESTERS | CRODA INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1469813-A2 | ADDITIVES AND PRODUCTS INCLUDING OLIGOESTERS | Croda, Inc. (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003063790-A2 | ADDITIVES AND PRODUCTS INCLUDING OLIGOESTERS | CRODA, INC. (US) | 2003-08-07 | — | — | WO | disclosed |
| US-3975350-A | HYDROPHILIC OR HYDROGEL CARRIER SYSTEMS SUCH AS COATINGS, BODY IMPLANTS AND TOHER ARTICLES | PRINCETON POLYMER LABORATORIES, INCORPORATED (US) | 1976-08-17 | — | — | US | disclosed |