SCHEMBL4586267

SCHEMBL4586267

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nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL700823 0.70 GRM4 (0.31)
SCHEMBL11131364 0.68
SCHEMBL20420817 0.68 HSD11B1 (0.41)
SCHEMBL17291846 0.68 GRM4 (0.30)
SCHEMBL8432762 0.67 TP53 (0.34) TP53RAB9A
SCHEMBL9670669 0.66 GRIN2D (0.35) TP53RAB9A
SCHEMBL18833223 0.65
SCHEMBL3419135 0.63 FFAR1 (0.35) RAB9A
SCHEMBL28330036 0.57
SCHEMBL27999703 0.56

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404864-A4 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS UNIV ROCKEFELLER (US) 2008-05-28 EP disclosed
US-7129073-B2 Regulation of neuronal function through metabotropic glutamate receptor signaling pathways THE ROCKEFELLER UNIVERSITY (US) 2006-10-31 US disclosed
US-20060223158-A1 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2006-10-05 US disclosed
EP-1404864-A2 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS THE ROCKEFELLER UNIVERSITY (US) 2004-04-07 EP disclosed
WO-2002102768-A2 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS THE ROCKEFELLER UNIVERSITY (US) 2002-12-27 WO disclosed