Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240053 | 0.78 | CCR5 (0.43) | CCR5 | |
| SCHEMBL4586330 | 0.77 | CARM1 (0.44) | CARM1PRMT6CCR5CYP2D6 | |
| SCHEMBL1348888 | 0.75 | PDE2A (0.57) | HTR2AHTR2CHTR7 | |
| SCHEMBL14708206 | 0.74 | JAK2 (0.46) | KDM4ECYP3A4TSHR | |
| SCHEMBL7985911 | 0.72 | KDM4E (0.49) | KDM4E | |
| SCHEMBL5756775 | 0.71 | HTR2A (0.66) | HTR2AHTR2CHTR7CARM1PRMT6 | |
| SCHEMBL26081058 | 0.71 | DHODH (0.50) | — | |
| SCHEMBL5760637 | 0.71 | HTR2A (0.64) | HTR2AHTR2CHTR7CARM1PRMT6 | |
| SCHEMBL17023785 | 0.70 | HRH1 (0.72) | HTR2AHTR2CCARM1PRMT6CCR5 | |
| SCHEMBL18590358 | 0.70 | HRH1 (0.72) | HTR2AHTR2CCARM1PRMT6CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |