Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.61 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585778 | 0.92 | MAPK13 (0.49) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4585076 | 0.89 | MAPK13 (0.57) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4584583 | 0.86 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4584568 | 0.83 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12BRAF | |
| SCHEMBL8860384 | 0.82 | BRAF (0.44) | MAPK14MAPK11MAPK13MAPK12BRAF | |
| SCHEMBL4585385 | 0.81 | ALOX5 (0.62) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL4586325 | 0.81 | MAPK13 (0.58) | MAPK14MAPK11MAPK13MAPK12RAF1 | |
| SCHEMBL4585395 | 0.79 | ALOX5 (0.61) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL4584739 | 0.76 | MAPK13 (1.00) | MAPK14MAPK11MAPK13MAPK12TRPV4 | |
| SCHEMBL1387629 | 0.75 | MAPK14 (0.65) | MAPK14MAPK11MAPK13MAPK12RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545535-A4 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1545535-A2 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004021988-A2 | TREATMENT OF PAIN BY INHIBITION OF P38 MAP KINASE | SCIOS INC. (US) | 2004-03-18 | — | — | WO | disclosed |
| US-5670527-A | CYTOKINE INHIBITORS USEFUL IN TREATING ASTHMA, OSTEOPOROSIS, ARTHRITIS, INFLAMMATION, SEPSIS, CARDIOVASCULAR DISORDERS, DIABETES, MULTIPLE SCLEROSIS, SKIN DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-23 | — | — | US | disclosed |