Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | HCK | P08631 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 8/20 | 0.57 |
| ▸ | LDLR | P01130 | 3/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.56 |
| ▸ | BCR | P11274 | 5/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587496 | 0.92 | CSF1R (0.56) | MAP4K2MAP3K7HCKKDRLCK | |
| SCHEMBL4588492 | 0.90 | ABL1 (0.58) | MAP4K2HCKKDRLCKLYN | |
| SCHEMBL14097647 | 0.89 | MAP3K7 (0.48) | MAP4K2MAP3K7HCKKDRLCK | |
| SCHEMBL4587278 | 0.89 | KDR (0.58) | MAP4K2HCKKDRLCKLYN | |
| SCHEMBL14097645 | 0.82 | KDM4E (0.43) | MAP4K2MAP3K7HCKKDRLCK | |
| SCHEMBL4586222 | 0.82 | PIKFYVE (0.57) | HCKKDRLCKLYNSRC | |
| SCHEMBL13269734 | 0.81 | SRC (0.58) | MAP4K2HCKKDRLCKLYN | |
| SCHEMBL3386095 | 0.81 | MAP4K2 (0.63) | MAP4K2MAP3K7HCKKDRLCK | |
| SCHEMBL20502614 | 0.79 | ABL1 (0.81) | HCKKDRLCKLYNSRC | |
| SCHEMBL4587765 | 0.79 | BRAF (0.53) | MAP4K2MAP3K7KDRLCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188483-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-08-07 | — | — | US | claimed |
| US-20080188483-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-08-07 | — | — | US | disclosed |
| US-20080188483-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188483-A1 | Compounds and Compositions as Protein Kinase Inhibitors | SRC, SGK2, PTK2B | MAP4K2 14/4885MAP3K7 41/4885HCK 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.