Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zafirlukast. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 known ✓ | Q9Y271 | 5/20 | 0.99 |
| ▸ | PLA2G4A | P47712 | 5/20 | 0.99 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.99 |
| ▸ | PPARG | P37231 | 4/20 | 0.99 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.99 |
| ▸ | MEN1 | O00255 | 1/20 | 0.99 |
| ▸ | PTGES | O14684 | 1/20 | 0.99 |
| ▸ | XPO1 | O14980 | 1/20 | 0.99 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.99 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.99 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.99 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.99 |
| ▸ | EGFR | P00533 | 1/20 | 0.99 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.99 |
| ▸ | PGR | P06401 | 1/20 | 0.99 |
| ▸ | POLB | P06746 | 1/20 | 0.99 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.99 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.99 |
| ▸ | MAPT | P10636 | 1/20 | 0.99 |
| ▸ | RARB | P10826 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zafirlukast SCHEMBL29861631 | 0.99 | PLA2G4A (1.00) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL29372773 | 0.99 | PLA2G4A (1.00) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL6600322 | 0.99 | PLA2G4A (1.00) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL4175 | 0.99 | PLA2G4A (1.00) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL30885065 | 0.99 | PLA2G4A (1.00) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL6765680 | 0.99 | PLA2G4A (0.99) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL8951202 | 0.99 | PLA2G4A (0.99) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL6378803 | 0.99 | PLA2G4A (0.99) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| Zafirlukast SCHEMBL6381072 | 0.99 | PLA2G4A (0.99) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 | |
| SCHEMBL4155891 | 0.98 | PLA2G4A (0.97) | PLA2G4ACYSLTR1EPHX2PPARGCYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383500-A4 | COMPOSITION AND METHOD FOR THE TREATMENT OF RESPIRATORY DISEASE | KAURA SITA R (US) | 2008-11-05 | — | — | EP | claimed |
| EP-1383500-A1 | COMPOSITION AND METHOD FOR THE TREATMENT OF RESPIRATORY DISEASE | Kaura, Sita R. (US) | 2004-01-28 | — | — | EP | claimed |
| US-20020198228-A1 | Composition and method for the treatment of respiratory desease | KAURA SITA R (US) | 2002-12-26 | — | — | US | claimed |
| WO-2002080916-A1 | COMPOSITION AND METHOD FOR THE TREATMENT OF RESPIRATORY DISEASE | KAURA SITA R (US) | 2002-10-17 | — | — | WO | claimed |
| CN-109071514-A | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-102274515-B | Medicinal composition containing montelukast and statins medicament | LIU SHUQIN | 2013-04-24 | — | — | CN | disclosed |
| CN-102274515-A | Medicinal composition containing montelukast and statins medicament | — | 2011-12-14 | — | — | CN | disclosed |