⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372653 | 0.76 | — | — | |
| SCHEMBL2063067 | 0.74 | ALDH1A1 (0.42) | — | |
| SCHEMBL5183130 | 0.72 | FFAR3 (0.33) | — | |
| SCHEMBL29743598 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL28915824 | 0.69 | — | — | |
| SCHEMBL27709007 | 0.68 | ALDH1A1 (0.41) | — | |
| SCHEMBL2078326 | 0.67 | ALDH1A1 (0.32) | — | |
| SCHEMBL1899520 | 0.67 | ALDH1A1 (0.50) | — | |
| SCHEMBL28151578 | 0.67 | TSHR (0.31) | — | |
| SCHEMBL2186415 | 0.66 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534823-A4 | THE USE OF ISOCYANATE LINKERS TO MAKE HYDROLYZABLE ACTIVE AGENT BIOPOLYMER CONJUGATES | BIOMARIN PHARM INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20060029586-A1 | Use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates | BIOMARIN PHARMACEUTICAL INC. | 2006-02-09 | — | — | US | disclosed |
| EP-1534823-A2 | THE USE OF ISOCYANATE LINKERS TO MAKE HYDROLYZABLE ACTIVE AGENT BIOPOLYMER CONJUGATES | BioMarin Pharmaceutical Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20040176270-A1 | Use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates | BIOMARIN PHARMACEUTICAL INC. | 2004-09-09 | — | — | US | disclosed |
| WO-2004008101-A2 | THE USE OF ISOCYANATE LINKERS TO MAKE HYDROLYZABLE ACTIVE AGENT BIOPOLYMER CONJUGATES | BIOMARIN PHARMACEUTICAL INC. (US) | 2004-01-22 | — | — | WO | disclosed |