Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL28445567 | 0.91 | ALDH1A1 (0.48) | ALDH1A1TSHRTDP1HDAC8MEN1 | |
| Styrene SCHEMBL27660332 | 0.89 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1PSIP1HDAC8 | |
| Styrene SCHEMBL10931561 | 0.88 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1HDAC8MCL1 | |
| Styrene SCHEMBL11159152 | 0.88 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1HDAC8MCL1 | |
| Styrene SCHEMBL1396668 | 0.87 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1HDAC8KMT2A | |
| Styrene SCHEMBL1261405 | 0.87 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1HDAC8KMT2A | |
| Styrene SCHEMBL5872292 | 0.85 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1PSIP1HDAC8 | |
| Styrene SCHEMBL15313173 | 0.85 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HDAC8KMT2A | |
| Styrene SCHEMBL4274360 | 0.85 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HDAC8KMT2A | |
| Styrene SCHEMBL5604788 | 0.85 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HDAC8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112011137-B | Graphene/water-soluble polymer composite material and preparation method thereof | 中国科学院化学研究所 | 2021-10-08 | — | — | CN | claimed |
| CN-110872380-B | graphene/MC nylon nano composite material and preparation method thereof | 中国科学院化学研究所 | 2021-01-26 | — | — | CN | claimed |
| US-7446834-B2 | Liquid crystal display device having refraction pattern aligned with black matrix thereof | INNOCOM TECHNOLOGY (SHENZHEN) CO., LTD. (CN) | 2008-11-04 | — | — | US | claimed |
| US-20070285610-A1 | Liquid crystal display device | INNOLUX DISPLAY CORP. | 2007-12-13 | — | — | US | claimed |
| CN-113543523-B | Substrate hole processing method and application thereof | 中国科学院化学研究所 | 2023-01-03 | — | — | CN | disclosed |
| CN-113314747-B | Sulfonated poly biphenyl proton exchange membrane with nano phase separation structure and preparation method thereof | 上海大学 | 2022-04-22 | — | — | CN | disclosed |
| CN-113314747-A | Sulfonated poly biphenyl proton exchange membrane with nano phase separation structure and preparation method thereof | 上海大学 | 2021-08-27 | — | — | CN | disclosed |
| US-20070285610-A1 | Liquid crystal display device | INNOLUX DISPLAY CORP. | 2007-12-13 | — | — | US | disclosed |