Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4587416 | 1.00 | CLK1 (0.36) | CLK1CLK2DYRK1ACISD1PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2993620 | 0.94 | CSF1R (0.37) | CLK1CLK2DYRK1ACISD1PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2993622 | 0.94 | CSF1R (0.37) | CLK1CLK2DYRK1ACISD1PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2998139 | 0.90 | SRC (0.40) | CISD1SRCTP53 | |
| Trifluoroacetic Acid SCHEMBL4586029 | 0.90 | SRC (0.40) | CISD1SRCTP53 | |
| Trifluoroacetic Acid SCHEMBL2985105 | 0.86 | CISD1 (0.39) | CLK1CLK2DYRK1ACISD1PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2985114 | 0.86 | CISD1 (0.39) | CLK1CLK2DYRK1ACISD1PIK3CD | |
| Trifluoroacetic Acid SCHEMBL2998142 | 0.85 | FABP3 (0.43) | CLK1CLK2DYRK1ACISD1PIK3CD | |
| SCHEMBL4585695 | 0.83 | CISD1 (0.41) | CLK1CLK2DYRK1ACISD1SRC | |
| SCHEMBL4585691 | 0.83 | CISD1 (0.41) | CLK1CLK2DYRK1ACISD1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |