Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869422 | 0.85 | CYP1A2 (0.54) | KDM4EMAPK1TDP1RAB9ACYP1A2 | |
| SCHEMBL29546077 | 0.85 | CYP1A2 (0.54) | KDM4EMAPK1TDP1RAB9ACYP1A2 | |
| SCHEMBL4589153 | 0.84 | RAB9A (0.39) | KDM4EMAPK1TDP1RAB9ACYP1A2 | |
| SCHEMBL835673 | 0.81 | CYP1A2 (0.51) | RAB9ACYP1A2CYP2A6SIGMAR1PDPK1 | |
| SCHEMBL14814417 | 0.80 | CYP1A2 (0.47) | KDM4EMAPK1TDP1RAB9ACYP1A2 | |
| SCHEMBL4523532 | 0.80 | CA1 (0.43) | TDP1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14085712 | 0.79 | KDM4E (0.74) | KDM4EMAPK1TDP1RAB9ANPC1 | |
| SCHEMBL16594736 | 0.79 | KDM4E (0.49) | KDM4EMAPK1TDP1RAB9ACYP1A2 | |
| SCHEMBL16594922 | 0.79 | KDM4E (0.49) | KDM4EMAPK1TDP1RAB9ACYP1A2 | |
| SCHEMBL7676690 | 0.78 | CYP1A2 (0.57) | RAB9ACYP1A2CYP2A6SIGMAR1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |