Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 15/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080362 | 0.91 | TBK1 (0.53) | TBK1MAP3K14IKBKE | |
| SCHEMBL10080690 | 0.90 | TBK1 (0.53) | TBK1MAP3K14IKBKE | |
| SCHEMBL15307922 | 0.84 | TBK1 (0.53) | TBK1MAP3K14IKBKE | |
| SCHEMBL435042 | 0.80 | TBK1 (0.53) | TBK1MAP3K14 | |
| SCHEMBL10080739 | 0.80 | TBK1 (0.49) | TBK1MAP3K14IKBKE | |
| SCHEMBL16667464 | 0.80 | TBK1 (0.51) | TBK1MAP3K14IKBKE | |
| SCHEMBL16667457 | 0.79 | TBK1 (0.51) | TBK1MAP3K14IKBKE | |
| SCHEMBL10080689 | 0.76 | TBK1 (0.53) | TBK1MAP3K14IKBKE | |
| SCHEMBL434250 | 0.74 | TBK1 (0.58) | TBK1MAP3K14IKBKE | |
| SCHEMBL16667459 | 0.74 | TBK1 (0.51) | TBK1MAP3K14IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595964-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Domainex Limited (GB) | 2013-05-29 | — | — | EP | claimed |
| WO-2012010826-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMAINEX LIMITED (GB) | 2012-01-26 | — | — | WO | claimed |
| EP-2595964-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Domainex Limited (GB) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010826-A1 | PYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES IKK EPSILON AND/OR TBK-1, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMAINEX LIMITED (GB) | 2012-01-26 | — | — | WO | disclosed |