Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283965 | 0.87 | MEN1 (0.47) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL19283959 | 0.84 | GCK (0.48) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL30717385 | 0.83 | MEN1 (0.46) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL19283878 | 0.82 | SLC29A1 (0.47) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL9095158 | 0.82 | MEN1 (0.54) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL3820812 | 0.81 | DHFR (0.54) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL20509404 | 0.79 | DHFR (0.55) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL19283880 | 0.79 | MEN1 (0.41) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL9094028 | 0.78 | MEN1 (0.52) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL3541178 | 0.77 | MEN1 (0.52) | MEN1KMT2AALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |