Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11885437 | 0.87 | MAPT (0.49) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL11885445 | 0.85 | KDM4E (0.47) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL13553399 | 0.80 | KDM4E (0.51) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL27337559 | 0.80 | HPGD (0.43) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL11886645 | 0.78 | KDM4E (0.49) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL13653654 | 0.77 | MAPT (0.51) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL8919957 | 0.76 | MAPT (0.50) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL29700504 | 0.75 | TACR1 (0.51) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL20690487 | 0.75 | TACR1 (0.51) | MAPTKDM4EHPGDALOX15SMN1; SMN2 | |
| SCHEMBL11118177 | 0.75 | CYP2C19 (0.71) | HPGDKMT2AMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100621-A2 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |