Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MITF | O75030 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zipeprol SCHEMBL364352 | 0.85 | GAA (0.47) | HIF1ATSHRCYP2D6ALDH1A1POLB | |
| Zipeprol SCHEMBL5563283 | 0.84 | GAA (0.46) | ALDH1A1LMNAPOLBKDM4EGAA | |
| Zipeprol SCHEMBL363879 | 0.84 | GAA (0.46) | ALDH1A1LMNAPOLBKDM4EGAA | |
| Zipeprol SCHEMBL1651193 | 0.83 | GAA (0.44) | HIF1ATSHRCYP2D6ALDH1A1POLB | |
| SCHEMBL11667975 | 0.79 | MEN1 (0.56) | HIF1ATSHRCYP2D6ALDH1A1MITF | |
| SCHEMBL3738538 | 0.79 | MEN1 (0.56) | HIF1ATSHRCYP2D6ALDH1A1MITF | |
| SCHEMBL17771722 | 0.78 | HIF1A (0.48) | HIF1ATSHRCYP2D6ALDH1A1MITF | |
| SCHEMBL17084131 | 0.77 | SLC22A2 (0.51) | HIF1ATSHRCYP2D6ALDH1A1MITF | |
| SCHEMBL17084199 | 0.77 | SLC22A2 (0.51) | HIF1ATSHRCYP2D6ALDH1A1MITF | |
| SCHEMBL17771721 | 0.76 | ALDH1A1 (0.49) | HIF1ATSHRCYP2D6ALDH1A1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100621-A2 | TETRAHYDRO-PYRAZOLO-PYRIDINE THIOETHER MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |