Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 6/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590280 | 0.84 | SUV39H2 (0.49) | FAAHSUV39H2 | |
| SCHEMBL4590279 | 0.84 | SUV39H2 (0.49) | FAAHSUV39H2 | |
| SCHEMBL4590454 | 0.81 | NPC1 (0.40) | NPC1FAAHCHRM4CTSBCTSS | |
| SCHEMBL27606539 | 0.77 | FAAH (0.54) | NPC1FAAHCHRM4NOTUMCTSB | |
| SCHEMBL20139213 | 0.77 | FAAH (0.54) | NPC1FAAHCHRM4NOTUMCTSB | |
| SCHEMBL23777734 | 0.76 | NOTUM (0.57) | NPC1FAAHNOTUM | |
| SCHEMBL8114412 | 0.74 | BCL2A1 (0.44) | — | |
| SCHEMBL4589715 | 0.74 | BCL2A1 (0.44) | — | |
| SCHEMBL4573983 | 0.73 | HRH3 (0.42) | NPC1FAAHCHRM4CHRM2CHRM1 | |
| SCHEMBL4573827 | 0.72 | NPC1 (0.43) | NPC1FAAHCHRM4NOTUMCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |