⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590897 | 0.55 | — | — | |
| SCHEMBL21582511 | 0.53 | — | — | |
| SCHEMBL1424748 | 0.48 | — | — | |
| SCHEMBL3937451 | 0.48 | — | — | |
| SCHEMBL10638296 | 0.47 | — | — | |
| SCHEMBL7265338 | 0.47 | — | — | |
| SCHEMBL6718539 | 0.39 | — | — | |
| SCHEMBL4584754 | 0.36 | — | — | |
| Hydroquinone SCHEMBL11511669 | 0.36 | ALOX15 (1.00) | — | |
| SCHEMBL2734601 | 0.35 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4570000-A | HISTAMINE HH-2 ANTAGONISTS; GASTROINTESTINAL DISORDERS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1986-02-11 | — | — | US | claimed |
| EP-0060696-B1 | NITROGEN HETEROCYCLES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-15 | — | — | EP | claimed |
| EP-0060696-A1 | Nitrogen heterocycles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-22 | — | — | EP | claimed |
| CN-114026082-B | Pyridin-3-yl derivatives | 爱杜西亚药品有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-112236424-B | Alkoxy-substituted pyridinyl derivatives | 爱杜西亚药品有限公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-3802517-B1 | ALKOXY-SUBSTITUTED PYRIDINYL DERIVATIVES AS LPA1 RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT OF FIBROSIS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-12-21 | — | — | EP | disclosed |
| CN-114026082-A | Pyridin-3-yl derivatives | 爱杜西亚药品有限公司 | 2022-02-08 | — | — | CN | disclosed |
| US-20210246116-A1 | ALKOXY-SUBSTITUTED PYRIDINYL DERIVATIVES AS LPA1 RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT OF FIBROSIS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-08-12 | — | — | US | disclosed |
| EP-3802517-A1 | ALKOXY-SUBSTITUTED PYRIDINYL DERIVATIVES AS LPA1 RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT OF FIBROSIS | Idorsia Pharmaceuticals Ltd (CH) | 2021-04-14 | — | — | EP | disclosed |
| CN-112236424-A | Alkoxy-substituted pyridyl derivatives | 爱杜西亚药品有限公司 | 2021-01-15 | — | — | CN | disclosed |
| WO-2019234115-A1 | ALKOXY-SUBSTITUTED PYRIDINYL DERIVATIVES AS LPA1 RECEPTOR ANTAGONISTS AND THEIR USE IN THE TREATMENT OF FIBROSIS | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-12-12 | — | — | WO | disclosed |
| US-8518976-B2 | e.g. 1-(3-(6-(2-fluorophenyl)pyridin-3-yl)propyl)-1H-pyridin-2-one; endothelial nitric oxide NO synthase inhibitor; antiinflammatory, hypotensive agent; atherosclerosis, thrombosis, coronary artery disease, and cardiac insufficiency | SANOFI (FR) | 2013-08-27 | — | — | US | disclosed |
| EP-1899321-B1 | HETEROARYL-SUBSTITUTED AMIDES COMPRISING A SATURATED LINKER GROUP, AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2011-12-28 | — | — | EP | disclosed |
| US-20080171739-A1 | Heteroaryl-Substituted Amides Comprising A Saturated Linker Group, And Their Use As Pharmaceuticals | SANOFI-AVENTIS (FR) | 2008-07-17 | — | — | US | disclosed |
| EP-1899321-A1 | HETEROARYL-SUBSTITUTED AMIDES COMPRISING A SATURATED LINKER GROUP, AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000246-A1 | HETEROARYL-SUBSTITUTED AMIDES COMPRISING A SATURATED LINKER GROUP, AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |
| US-4570000-A | HISTAMINE HH-2 ANTAGONISTS; GASTROINTESTINAL DISORDERS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1986-02-11 | — | — | US | disclosed |
| EP-0060696-B1 | NITROGEN HETEROCYCLES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-15 | — | — | EP | disclosed |
| US-4460584-A | GUANIDINE DERIVATIVES, ANTISECRETORY AGENT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-07-17 | — | — | US | disclosed |
| EP-0060696-A1 | Nitrogen heterocycles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-22 | — | — | EP | disclosed |