Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73135 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EATMALDH1A1HPGD | |
| SCHEMBL73134 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EATMALDH1A1HPGD | |
| SCHEMBL4574462 | 0.86 | KDM4E (0.39) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL74012 | 0.82 | PDE5A (0.40) | SMN1; SMN2PDE4D | |
| SCHEMBL8190655 | 0.82 | AKR1C3 (0.38) | SMN1; SMN2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL74013 | 0.82 | PDE5A (0.40) | SMN1; SMN2PDE4D | |
| SCHEMBL4574938 | 0.80 | MEN1 (0.38) | SMN1; SMN2KDM4EALDH1A1MAPK1NPC1 | |
| SCHEMBL74642 | 0.72 | PDE4A (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDPDE4D | |
| SCHEMBL5973105 | 0.69 | ALDH1A1 (0.38) | KDM4EALDH1A1HTTNPC1RAB9A | |
| SCHEMBL6605487 | 0.68 | NPC1 (0.38) | KDM4EALDH1A1NPC1RAB9APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008081282-A2 | PROCESS FOR THE SYNTHESIS OF N9-(3,5-DICHLORO-4-PYRIDYL)-6- DIFLUOROMETHOXYBENZO(4,5)FURO(3,2-C)PYRIDINE-9-CARBOXAMIDE AND SALTS THEREOF | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-07-10 | — | — | WO | disclosed |