SCHEMBL4591045

SCHEMBL4591045

Cc1c(C)n(Cc2ccccc2)c2c(OCc3ccccc3C(C)O)nncc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
FABP4 P15090 1/20 0.39
TSHR P16473 3/20 0.35
MAPK1 P28482 2/20 0.35
HTT P42858 2/20 0.35
LMNA P02545 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
KDM4E B2RXH2 2/20 0.33
NR2F2 P24468 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4591520 0.86 CYP1A2 (0.46) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9738417 0.85 CYP1A2 (0.46) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9754166 0.84 CYP1A2 (0.44) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9738063 0.82 CYP1A2 (0.46) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9754149 0.81 FABP4 (0.42) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9754471 0.80 FABP4 (0.41) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9754136 0.80 FABP4 (0.41) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9754353 0.80 FABP4 (0.41) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9738231 0.79 CYP2D6 (0.47) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9
SCHEMBL9739195 0.79 CYP1A2 (0.48) CYP3A4CYP2D6CYP2C19CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879891-A1 MUTUAL PRODRUG COMPOUNDS FOR USE AS ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECTIVE ACTIVITY Nycomed GmbH (DE) 2008-01-23 EP claimed
EP-1877410-A1 MUTUAL PRODRUG COMPOUNDS FOR USE AS ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECTIVE ACTIVITY Nycomed GmbH (DE) 2008-01-16 EP claimed
WO-2006117315-A1 MUTUAL PRODRUG COMPOUNDS FOR USE AS ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECCTIVE ACTIVITY NYCOMED GMBH (DE) 2006-11-09 WO claimed
WO-2006117316-A1 MUTUAL PRODRUG COMPOUNDS FOR USE US ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECTIVE ACTIVITY NYCOMED GMBH (DE) 2006-11-09 WO claimed
EP-1879891-A1 MUTUAL PRODRUG COMPOUNDS FOR USE AS ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECTIVE ACTIVITY Nycomed GmbH (DE) 2008-01-23 EP disclosed
EP-1877410-A1 MUTUAL PRODRUG COMPOUNDS FOR USE AS ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECTIVE ACTIVITY Nycomed GmbH (DE) 2008-01-16 EP disclosed
WO-2006117315-A1 MUTUAL PRODRUG COMPOUNDS FOR USE AS ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECCTIVE ACTIVITY NYCOMED GMBH (DE) 2006-11-09 WO disclosed
WO-2006117316-A1 MUTUAL PRODRUG COMPOUNDS FOR USE US ANTIINFLAMMATORY AGENTS WITH GASTROINTESTINAL PROTECTIVE ACTIVITY NYCOMED GMBH (DE) 2006-11-09 WO disclosed