⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032708 | 0.66 | CYP3A4 (0.34) | — | |
| SCHEMBL1140198 | 0.64 | — | — | |
| SCHEMBL333505 | 0.60 | — | — | |
| SCHEMBL14953658 | 0.59 | — | — | |
| SCHEMBL1927501 | 0.59 | — | — | |
| SCHEMBL7082937 | 0.59 | — | — | |
| SCHEMBL7776632 | 0.59 | — | — | |
| SCHEMBL1545443 | 0.57 | — | — | |
| SCHEMBL17186581 | 0.57 | — | — | |
| SCHEMBL1825647 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0053961-B1 | THIOVINYL-3-CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC SANTE (FR) | 1984-10-24 | — | — | EP | claimed |
| EP-0113965-A2 | Process for the preparation of cephalosporin derivatives | ICI PHARMA (FR) | 1984-07-25 | — | — | EP | claimed |
| US-4415562-A | 3-Thiovinylcephalosporins and pharmaceutical compositions | RHONE-POULENC INDUSTRIES (FR) | 1983-11-15 | — | — | US | claimed |
| EP-0082648-A2 | Cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-29 | — | — | EP | claimed |
| US-4385181-A | CHAMICAL INTERMEDIATES FOR CEPHALOSPORINS | RHONE POULENC INDUSTRIES (FR) | 1983-05-24 | — | — | US | claimed |
| EP-0072608-A2 | Process for the preparation of cephalosporin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-02-23 | — | — | EP | claimed |
| EP-0071370-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | ICI PHARMA (FR) | 1983-02-09 | — | — | EP | claimed |
| US-4307116-A | BACTERICIDES | RHONE-POULENC INDUSTRIES (FR) | 1981-12-22 | — | — | US | claimed |
| EP-2964209-B1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | LEVOLTA PHARMACEUTICALS INC (US) | 2021-10-27 | — | — | EP | disclosed |
| US-9737553-B2 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis | LEVOLTA PHARMACEUTICALS, INC. (US) | 2017-08-22 | — | — | US | disclosed |
| EP-2964209-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | Levolta Pharmaceuticals, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| US-20150031649-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | VOLTARRA PHARMACEUTICALS, INC. (US) | 2015-01-29 | — | — | US | disclosed |
| US-8859530-B2 | Co-administration of steroids and zoledronic acid to prevent and treat osteoarthritis | VOLTARRA PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2014138712-A1 | CO-ADMINISTRATION OF STEROIDS AND ZOLEDRONIC ACID TO PREVENT AND TREAT OSTEOARTHRITIS | VOLTARRA PHARMACEUTICALS, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| US-4369315-A | ANTIBIOTIC | RHONE-POULENC INDUSTRIES (FR) | 1983-01-18 | — | — | US | disclosed |
| US-4365062-A | BACTERICIDAL ANTIBIOTICS | RHONE-POULENC INDUSTRIES (FR) | 1982-12-21 | — | — | US | disclosed |
| US-4307233-A | ANTIBACTERIAL AGENTS | RHONE-POULENC INDUSTRIES (FR) | 1981-12-22 | — | — | US | disclosed |
| US-4307116-A | BACTERICIDES | RHONE-POULENC INDUSTRIES (FR) | 1981-12-22 | — | — | US | disclosed |
| US-4307230-A | ANTIBIOTICS | RHONE-POULENC INDUSTRIES (FR) | 1981-12-22 | — | — | US | disclosed |
| US-4278793-A | ANTIBIOTICS, BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-14 | — | — | US | disclosed |