Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202462 | 1.00 | L3MBTL1 (0.65) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3202454 | 1.00 | L3MBTL1 (0.65) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3196357 | 0.84 | L3MBTL1 (0.51) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3196361 | 0.84 | L3MBTL1 (0.51) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3178691 | 0.83 | TSHR (0.82) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3178679 | 0.83 | TSHR (0.82) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3191311 | 0.83 | L3MBTL1 (0.50) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3191710 | 0.81 | KMT2A (0.44) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3192339 | 0.79 | L3MBTL1 (0.70) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 | |
| SCHEMBL3192332 | 0.79 | L3MBTL1 (0.70) | L3MBTL1TSHRCYP3A4CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379249-A4 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1379249-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | Bristol-Myers Squibb Company (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002067939-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-06 | — | — | WO | claimed |