Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198852 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3198842 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3199810 | 0.92 | POLB (0.56) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3199805 | 0.92 | POLB (0.56) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3181265 | 0.82 | L3MBTL1 (0.47) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL5922888 | 0.82 | MEN1 (0.51) | KDM4EHPGDKMT2ATSHRNPSR1 | |
| SCHEMBL3181268 | 0.82 | L3MBTL1 (0.47) | SMN1; SMN2KDM4ENPC1HPGDRAB9A | |
| SCHEMBL3186156 | 0.80 | TSHR (0.61) | SMN1; SMN2KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL3186148 | 0.80 | TSHR (0.61) | SMN1; SMN2KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL3198727 | 0.80 | TSHR (0.61) | SMN1; SMN2KDM4EHPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379249-A4 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1379249-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | Bristol-Myers Squibb Company (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002067939-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-06 | — | — | WO | claimed |