SCHEMBL459183

SCHEMBL459183

CCCc1cc(CN)on1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 1/20 0.43
NOTUM Q6P988 3/20 0.42
AURKA O14965 1/20 0.37
DAPK3 O43293 1/20 0.37
JAK2 O60674 1/20 0.37
ROCK2 O75116 1/20 0.37
CHEK2 O96017 1/20 0.37
PIM1 P11309 1/20 0.37
CDK2 P24941 1/20 0.37
MARK3 P27448 1/20 0.37
GSK3A P49840 1/20 0.37
GSK3B P49841 1/20 0.37
LIMK1 P53667 1/20 0.37
CDK5 Q00535 1/20 0.37
ROCK1 Q13464 1/20 0.37
DYRK1A Q13627 1/20 0.37
AURKB Q96GD4 1/20 0.37
PRKD2 Q9BZL6 1/20 0.37
CYP2E1 P05181 1/20 0.37
CYP2A6 P11509 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25653948 0.89 PPARA (0.51) PPARANOTUMCYP2E1CYP2A6CYP2C9
SCHEMBL8605187 0.87 PPARA (0.57) PPARANOTUMCYP2E1CYP2A6CYP2C9
SCHEMBL456435 0.84 PPARA (0.43) PPARARAB9ANPC1SMN1; SMN2S1PR1
SCHEMBL12450498 0.83 PPARA (0.45) PPARAAURKADAPK3JAK2ROCK2
SCHEMBL443027 0.83
Hydrochloric Acid SCHEMBL4302835 0.82 NOTUM (0.43) PPARANOTUMCYP2E1CYP2A6CYP2C9
SCHEMBL875922 0.80 PPARA (0.43) PPARAAURKADAPK3JAK2ROCK2
SCHEMBL9849583 0.80 NOTUM (0.42) PPARANOTUMCYP2E1CYP2A6CYP2C9
SCHEMBL6896391 0.80 PPARA (0.46) PPARANOTUMAURKADAPK3JAK2
SCHEMBL1715078 0.79 PPARA (0.40) PPARAAURKADAPK3JAK2ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024028779-A1 AMANITA MUSCARIA VAPORIZER FORMULATIONS AND DEVICES PSYCHED WELLNESS LTD. (CA) 2024-02-08 WO disclosed
EP-3826679-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS F. Hoffmann-La Roche AG (CH) 2021-06-02 EP disclosed
WO-2020021097-A1 COMPOUNDS FOR USE IN TREATING KIDNEY DISORDERS F. HOFFMANN-LA ROCHE AG (CH) 2020-01-30 WO disclosed
EP-2613785-A1 HETEROARYLMETHYL AMIDES F.HOFFMANN-LA ROCHE AG (CH) 2013-07-17 EP disclosed
WO-2012032018-A1 HETEROARYLMETHYL AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2012-03-15 WO disclosed