Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 12/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456678 | 0.89 | PPARA (0.51) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL459183 | 0.84 | PPARA (0.43) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL10154648 | 0.83 | PPARA (0.45) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL2093099 | 0.80 | PPARA (0.46) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL6003333 | 0.80 | PPARA (0.43) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL25013973 | 0.77 | PPARA (0.41) | PPARA | |
| SCHEMBL20427474 | 0.77 | RAB9A (0.49) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL21690292 | 0.77 | PPARA (0.41) | PPARARAB9ANPC1SMN1; SMN2S1PR1 | |
| SCHEMBL25653948 | 0.77 | PPARA (0.51) | PPARARAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL19214843 | 0.77 | RAB9A (0.39) | PPARARAB9ANPC1SMN1; SMN2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613785-A1 | HETEROARYLMETHYL AMIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032018-A1 | HETEROARYLMETHYL AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |