Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | GNRHR | P30968 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450134 | 1.00 | NAMPT (0.51) | NAMPTKDM4EPKMMEN1KMT2A | |
| SCHEMBL3450135 | 1.00 | NAMPT (0.51) | NAMPTKDM4EPKMMEN1KMT2A | |
| SCHEMBL29527235 | 0.94 | KDM4E (0.58) | NAMPTKDM4EPKMMEN1KMT2A | |
| SCHEMBL22777318 | 0.94 | KDM4E (0.58) | NAMPTKDM4EPKMMEN1KMT2A | |
| SCHEMBL4592410 | 0.85 | NPC1 (0.49) | NAMPTKMT2AHRH4HDAC3HDAC1 | |
| SCHEMBL22373791 | 0.85 | HRH4 (0.52) | HRH4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21819725 | 0.83 | ATF4 (0.52) | HRH4MAPK8NPC1RAB9ASTS | |
| SCHEMBL29082741 | 0.81 | KMT2A (0.55) | NAMPTKMT2AHRH4NPC1RAB9A | |
| SCHEMBL3448188 | 0.81 | KDM4E (0.69) | NAMPTKDM4EPKMMEN1KMT2A | |
| SCHEMBL3448190 | 0.81 | KDM4E (0.69) | NAMPTKDM4EPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877404-A2 | NOVEL CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |