Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.73 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.52 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CBS | P35520 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.44 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10338016 | 0.86 | ELANE (0.97) | ELANEMAPTLMNAHTTFFAR1 | |
| SCHEMBL10337743 | 0.86 | ELANE (0.92) | ELANEMAPTLMNAHTTFFAR1 | |
| SCHEMBL10337787 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10338012 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10337784 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10337783 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10337865 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10337604 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10337989 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE | |
| SCHEMBL10338015 | 0.85 | ELANE (1.00) | ELANEMAPTLMNAHTTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772332-B2 | Arylpropionyl-alpha-pyrone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-07-08 | — | — | US | disclosed |
| US-20130296421-A1 | ARYLPROPIONYL-ALPHA-PYRONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-11-07 | — | — | US | disclosed |
| WO-2012033815-A1 | ARYLPROPIONYL-ALPHA-PYRONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296421-A1 | ARYLPROPIONYL-ALPHA-PYRONE ANTIBACTERIAL AGENTS | QRFPR, MRPL21, BET1 | ELANE 827/4885SLC5A1 784/4885SLC5A2 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.