Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 1/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.47 |
| ▸ | IL1RN | P18510 | 3/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591388 | 0.94 | GPR84 (0.52) | ECE1ERAP2IL1RNERAP1GPR84 | |
| SCHEMBL4858383 | 0.80 | MEN1 (0.61) | GPR84FFAR1MEN1KMT2AMAPT | |
| SCHEMBL21067833 | 0.80 | MEN1 (0.61) | GPR84FFAR1MEN1KMT2AMAPT | |
| SCHEMBL28224620 | 0.79 | GPR84 (0.52) | GPR84FFAR1MEN1KMT2AMAPT | |
| SCHEMBL16634428 | 0.78 | HDAC3 (0.55) | GPR84FFAR1MMP2MMP9MMP8 | |
| SCHEMBL1306986 | 0.77 | HDAC3 (0.63) | ECE1GPR84FFAR1MMP2MMP9 | |
| SCHEMBL19612657 | 0.77 | GPR84 (0.55) | GPR84FFAR1MEN1KMT2AMAPT | |
| SCHEMBL1306793 | 0.77 | HDAC3 (0.56) | ECE1GPR84FFAR1MMP2MMP9 | |
| SCHEMBL1306368 | 0.76 | HDAC3 (0.68) | ECE1GPR84FFAR1MMP2MMP9 | |
| SCHEMBL28860693 | 0.76 | MEN1 (0.59) | GPR84FFAR1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891007-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006131484-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-12-14 | — | — | WO | disclosed |