Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 11/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591473 | 0.92 | TACR1 (0.41) | SSTR5KCNH2TACR1HTR2A | |
| SCHEMBL4629774 | 0.88 | SSTR5 (0.40) | SSTR5KCNH2TACR1HTR2A | |
| SCHEMBL4591860 | 0.86 | TACR1 (0.45) | KCNH2TACR1 | |
| SCHEMBL4591464 | 0.81 | REN (0.38) | KCNH2TACR1HTR2A | |
| SCHEMBL4591930 | 0.80 | POLB (0.42) | SSTR5KCNH2TACR1HTR2A | |
| SCHEMBL4591887 | 0.78 | TACR1 (0.45) | KCNH2TACR1HTR2A | |
| SCHEMBL4591455 | 0.78 | TACR1 (0.37) | KCNH2TACR1HTR2A | |
| SCHEMBL4591939 | 0.77 | SLC6A4 (0.38) | KCNH2TACR1HTR2A | |
| SCHEMBL4591832 | 0.77 | HTR2A (0.40) | KCNH2TACR1HTR2A | |
| SCHEMBL4591515 | 0.77 | REN (0.39) | KCNH2TACR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | claimed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | claimed |
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | disclosed |