Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | PRSS12 | P56730 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592193 | 0.92 | PRSS12 (0.51) | CHRNA7HTR3APRSS12SLC6A2SLC6A4 | |
| SCHEMBL4592190 | 0.92 | PRSS12 (0.51) | CHRNA7HTR3APRSS12SLC6A2SLC6A4 | |
| SCHEMBL3449291 | 0.86 | ACKR3 (0.54) | CHRNA7HTR3AKMT2AF10NAMPT | |
| SCHEMBL3449294 | 0.86 | ACKR3 (0.54) | CHRNA7HTR3AKMT2AF10NAMPT | |
| SCHEMBL4592249 | 0.86 | ACKR3 (0.54) | CHRNA7HTR3AKMT2AF10NAMPT | |
| SCHEMBL13126312 | 0.85 | CHRNA7 (0.46) | CHRNA7HTR3APRSS12KMT2AF10 | |
| SCHEMBL4592552 | 0.79 | F10 (0.52) | F10 | |
| SCHEMBL4592548 | 0.79 | F10 (0.52) | F10 | |
| SCHEMBL4592410 | 0.78 | NPC1 (0.49) | CHRNA7HTR3ASLC6A2SLC6A4KMT2A | |
| SCHEMBL3447771 | 0.78 | ACKR3 (0.54) | CHRNA7PRSS12KMT2AF10NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877404-A2 | NOVEL CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |