Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3189623 | 1.00 | CA1 (0.60) | CA1CA2TSHRCYP3A4CYP2C19 | |
| SCHEMBL3189633 | 1.00 | CA1 (0.60) | CA1CA2TSHRCYP3A4CYP2C19 | |
| SCHEMBL4020740 | 0.90 | TSHR (0.66) | TSHRCYP3A4CYP2C19NPSR1ATM | |
| SCHEMBL14494361 | 0.87 | TSHR (0.51) | CA1CA2TSHRCYP3A4CYP2C19 | |
| SCHEMBL3181073 | 0.83 | USP2 (0.57) | CA1CA2TSHRCYP3A4CYP2C19 | |
| SCHEMBL3181082 | 0.83 | USP2 (0.57) | CA1CA2TSHRCYP3A4CYP2C19 | |
| SCHEMBL3186527 | 0.83 | USP2 (0.57) | CA1CA2TSHRCYP3A4CYP2C19 | |
| SCHEMBL13841525 | 0.83 | KMT2A (0.60) | TSHRCYP3A4CYP2C19NPSR1ATM | |
| SCHEMBL18827744 | 0.83 | KMT2A (0.60) | TSHRCYP3A4CYP2C19NPSR1ATM | |
| SCHEMBL3198224 | 0.83 | TSHR (0.66) | CA1CA2TSHRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379249-A4 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1379249-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | Bristol-Myers Squibb Company (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002067939-A1 | FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-06 | — | — | WO | claimed |