Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.85 |
| ▸ | RAB9A | P51151 | 12/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.85 |
| ▸ | GAA | P10253 | 5/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.85 |
| ▸ | HPGD | P15428 | 3/20 | 0.85 |
| ▸ | LMNA | P02545 | 3/20 | 0.85 |
| ▸ | HTT | P42858 | 3/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GFER | P55789 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764284 | 0.83 | NPC1 (0.66) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL12953805 | 0.78 | NPC1 (0.58) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL15213084 | 0.77 | NPC1 (0.53) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL15201373 | 0.77 | MAPT (0.60) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL784053 | 0.76 | NPC1 (0.69) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL12047771 | 0.76 | RAB9A (0.65) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL212384 | 0.76 | NPC1 (0.71) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL12010963 | 0.75 | KDM4E (0.76) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL20459538 | 0.74 | NPC1 (0.59) | NPC1RAB9AKDM4EGAASMN1; SMN2 | |
| SCHEMBL19553580 | 0.73 | NPC1 (0.54) | NPC1RAB9AKDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071810-B2 | 3-(3-Amino-2,6-diisopropyl-phenyl)-1-(4-isopropyl-phenyl)-1-(4-methoxy-benzyl)-urea; autoimmune disorders; inflammation | JERINI AG (DE) | 2011-12-06 | — | — | US | disclosed |
| US-8071810-B2 | 3-(3-Amino-2,6-diisopropyl-phenyl)-1-(4-isopropyl-phenyl)-1-(4-methoxy-benzyl)-urea; autoimmune disorders; inflammation | JERINI AG (DE) | 2011-12-06 | — | — | US | disclosed |
| US-8071810-B2 | 3-(3-Amino-2,6-diisopropyl-phenyl)-1-(4-isopropyl-phenyl)-1-(4-methoxy-benzyl)-urea; autoimmune disorders; inflammation | JERINI AG (DE) | 2011-12-06 | — | — | US | disclosed |
| US-20080220003-A1 | C5a Receptor Antagonists | JERINI AG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080220003-A1 | C5a Receptor Antagonists | JERINI AG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080220003-A1 | C5a Receptor Antagonists | JERINI AG (DE) | 2008-09-11 | — | — | US | disclosed |
| EP-1885691-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| EP-1739078-A1 | Antagonists of C5a-receptor | Jerini AG (DE) | 2007-01-03 | — | — | EP | disclosed |
| EP-1739078-A1 | Antagonists of C5a-receptor | Jerini AG (DE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2006128670-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080220003-A1 | C5a Receptor Antagonists | C3AR1, C5AR2, C5AR1 | NPC1 3793/4885RAB9A 2366/4885KDM4E 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.