Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 6/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592636 | 1.00 | KDM4E (0.32) | KDM4EALDH1A1POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL4592456 | 0.92 | PTK2 (0.35) | KDM4EPOLBSMN1; SMN2PTK2TP53 | |
| SCHEMBL5050236 | 0.85 | MEN1 (0.39) | ALDH1A1SMN1; SMN2UTS2RMEN1KMT2A | |
| SCHEMBL5049341 | 0.85 | MEN1 (0.39) | ALDH1A1SMN1; SMN2UTS2RMEN1KMT2A | |
| SCHEMBL5049344 | 0.85 | MEN1 (0.39) | ALDH1A1SMN1; SMN2UTS2RMEN1KMT2A | |
| SCHEMBL4591956 | 0.84 | UTS2R (0.34) | ALDH1A1SMN1; SMN2UTS2R | |
| SCHEMBL4591954 | 0.84 | UTS2R (0.34) | ALDH1A1SMN1; SMN2UTS2R | |
| SCHEMBL4592323 | 0.84 | UTS2R (0.34) | ALDH1A1SMN1; SMN2UTS2R | |
| SCHEMBL4592692 | 0.83 | PTK2 (0.37) | KDM4EALDH1A1POLBPTK2TP53 | |
| SCHEMBL4591774 | 0.82 | CTSD (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885691-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2008-02-13 | — | — | EP | claimed |
| WO-2006128670-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-12-07 | — | — | WO | claimed |