Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 3/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | RAC1 | P63000 | 2/20 | 0.41 |
| ▸ | RAC2 | P15153 | 1/20 | 0.41 |
| ▸ | RAC3 | P60763 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403151 | 1.00 | GAK (0.43) | GAKNCF1ADRB2RAC1RAC2 | |
| SCHEMBL1461737 | 0.85 | GAK (0.46) | GAKNCF1ADRB2RAC1RAC2 | |
| SCHEMBL12968479 | 0.84 | GAK (0.47) | GAKNCF1ADRB2RAC1RAC2 | |
| SCHEMBL15473239 | 0.82 | GAK (0.48) | GAKNCF1ADRB2PARP1AAK1 | |
| SCHEMBL22809487 | 0.82 | GAK (0.45) | GAKNCF1ADRB2RAC1RAC2 | |
| SCHEMBL4419956 | 0.82 | GAK (0.45) | GAKNCF1ADRB2RAC1RAC2 | |
| SCHEMBL4150418 | 0.80 | LMNA (0.48) | — | |
| SCHEMBL7503944 | 0.78 | CYP11B1 (0.58) | GAKNCF1ADRB2PARP1GRM4 | |
| SCHEMBL2797692 | 0.77 | GAK (0.64) | GAKNCF1ADRB2PARP1AAK1 | |
| SCHEMBL4146513 | 0.77 | RAC1 (0.54) | GAKNCF1ADRB2RAC1RAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910334-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF AMYLOID-BETA-PEPTIDE RELATED DISORDERS | Exonhit Therapeutics SA (FR) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007034329-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF AMYLOID-BETA-PEPTIDE RELATED DISORDERS | EXONHIT THERAPEUTICS SA (FR) | 2007-03-29 | — | — | WO | disclosed |