Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447823 | 1.00 | ACKR3 (0.56) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL3447821 | 1.00 | ACKR3 (0.56) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL3448652 | 0.91 | ACKR3 (0.55) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL3448647 | 0.91 | ACKR3 (0.55) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL4592403 | 0.91 | ACKR3 (0.55) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL3449148 | 0.85 | ACKR3 (0.66) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL3449150 | 0.85 | ACKR3 (0.66) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL4592230 | 0.85 | ACKR3 (0.66) | ACKR3KDM4EPKMIDO1TDO2 | |
| SCHEMBL4592619 | 0.84 | ACKR3 (0.39) | ACKR3MEN1KMT2AKCNH2CACNA1I | |
| SCHEMBL3449326 | 0.80 | ACKR3 (0.65) | ACKR3KDM4EPKMIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877404-A2 | NOVEL CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |