Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592977 | 0.94 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4600776 | 0.90 | NPC1 (0.33) | NPC1RAB9ASMN1; SMN2TP53GFER | |
| SCHEMBL4592560 | 0.86 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2TP53GFER | |
| SCHEMBL4593086 | 0.85 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2TP53GFER | |
| SCHEMBL4592886 | 0.82 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2TP53GFER | |
| SCHEMBL4592695 | 0.77 | UTS2R (0.35) | — | |
| SCHEMBL4592696 | 0.77 | UTS2R (0.35) | — | |
| SCHEMBL4592378 | 0.77 | CNR2 (0.39) | SMN1; SMN2POLBLMNA | |
| SCHEMBL4592549 | 0.76 | CNR2 (0.39) | SMN1; SMN2POLBLMNA | |
| SCHEMBL4592260 | 0.75 | UTS2R (0.36) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885691-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2008-02-13 | — | — | EP | claimed |
| WO-2006128670-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-12-07 | — | — | WO | claimed |