Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592978 | 0.90 | NPC1 (0.34) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL4592560 | 0.89 | NPC1 (0.39) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL4593086 | 0.88 | NPC1 (0.38) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL4592977 | 0.87 | NPC1 (0.32) | NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4592886 | 0.82 | NPC1 (0.40) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL4591425 | 0.78 | MAPT (0.37) | NPC1RAB9APOLBSMN1; SMN2MAPT | |
| SCHEMBL4592219 | 0.75 | MAPT (0.37) | NPC1RAB9APOLBSMN1; SMN2TP53 | |
| SCHEMBL4592887 | 0.74 | QPCT (0.31) | NPC1RAB9AKMT2A | |
| SCHEMBL4592695 | 0.74 | UTS2R (0.35) | — | |
| SCHEMBL4592696 | 0.74 | UTS2R (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885691-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006128670-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-12-07 | — | — | WO | disclosed |