Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593203 | 0.94 | TP53 (0.43) | KMT2AMEN1TP53GAATSHR | |
| SCHEMBL2825483 | 0.83 | TSHR (0.56) | KMT2AMEN1TP53GAATSHR | |
| SCHEMBL2825539 | 0.80 | PIM1 (0.57) | KMT2AMEN1TP53GAATSHR | |
| SCHEMBL2825529 | 0.79 | L3MBTL1 (0.48) | KMT2AMEN1GAATSHRATM | |
| SCHEMBL4593198 | 0.79 | KMT2A (0.59) | KMT2AMEN1GAATSHRPOLB | |
| SCHEMBL4592280 | 0.78 | KMT2A (0.53) | KMT2AMEN1TP53GAATSHR | |
| SCHEMBL2830358 | 0.78 | KMT2A (0.53) | KMT2AMEN1GAATSHRBACE1 | |
| SCHEMBL2827281 | 0.77 | TSHR (0.55) | KMT2AMEN1TP53GAATSHR | |
| SCHEMBL2827781 | 0.74 | BACE1 (0.49) | KMT2ATSHRBACE1FLT3 | |
| SCHEMBL2827855 | 0.73 | KMT2A (0.54) | KMT2AMEN1GAATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948648-A2 | 3-ARYL-ISOXAZOLE-4-CARBONYL-BENZOFURAN DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054444-A2 | 3-ARYL-ISOXAZOLE-4-CARBONYL-BENZOFURAN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-18 | — | — | WO | disclosed |