Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377247 | 0.83 | ATM (0.55) | ATMPIK3C3JAK2HDAC1HDAC6 | |
| SCHEMBL8239261 | 0.80 | JAK2 (0.53) | ATMPIK3C3JAK2HDAC1HDAC6 | |
| SCHEMBL4383414 | 0.69 | JAK2 (0.53) | JAK2HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL4378262 | 0.67 | JAK2 (0.70) | JAK2HDAC1HDAC6LMNAALDH1A1 | |
| SCHEMBL29808901 | 0.67 | JAK2 (0.53) | JAK2HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL21121003 | 0.67 | JAK2 (0.53) | JAK2HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL2763208 | 0.67 | MAPT (0.64) | ATMPKMNPC1RAB9AMEN1 | |
| SCHEMBL13588617 | 0.66 | JAK2 (0.65) | JAK2HDAC1HDAC6LMNAALDH1A1 | |
| SCHEMBL5832095 | 0.66 | ATM (0.62) | ATMJAK2NPC1RAB9AMET | |
| SCHEMBL5831179 | 0.65 | ATM (0.65) | ATMPKMMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |