Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377247 | 0.96 | ATM (0.55) | JAK2HDAC1HDAC6ATMJAK3 | |
| SCHEMBL13588617 | 0.83 | JAK2 (0.65) | JAK2HDAC1HDAC6JAK3ABL1 | |
| SCHEMBL4378262 | 0.83 | JAK2 (0.70) | JAK2HDAC1HDAC6JAK3ABL1 | |
| SCHEMBL4593107 | 0.80 | ATM (0.53) | JAK2HDAC1HDAC6ATMJAK3 | |
| SCHEMBL4379855 | 0.80 | JAK2 (0.59) | JAK2HDAC1HDAC6JAK3ABL1 | |
| SCHEMBL4380161 | 0.78 | JAK2 (0.61) | JAK2HDAC1HDAC6JAK3ABL1 | |
| SCHEMBL4593985 | 0.76 | JAK2 (0.51) | JAK2HDAC1HDAC6JAK3ABL1 | |
| SCHEMBL4381621 | 0.73 | JAK2 (0.69) | JAK2HDAC1HDAC6ABL1MAP3K5 | |
| SCHEMBL4383459 | 0.71 | JAK2 (0.82) | JAK2HDAC1HDAC6JAK3 | |
| SCHEMBL3762937 | 0.71 | JAK2 (0.56) | JAK2HDAC1HDAC6JAK3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |