Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 15/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594894 | 0.91 | SSTR5 (0.38) | SSTR5KCNH2SSTR1GRK5HDAC6 | |
| SCHEMBL4594470 | 0.89 | SSTR5 (0.36) | SSTR5KCNH2SSTR1SSTR3GRK5 | |
| SCHEMBL4593240 | 0.88 | SSTR5 (0.36) | SSTR5KCNH2SSTR1SSTR3SLC6A2 | |
| SCHEMBL4593292 | 0.88 | SSTR5 (0.39) | SSTR5KCNH2SSTR1GRK5SLC6A2 | |
| SCHEMBL4594815 | 0.87 | NPC1 (0.40) | SSTR5KCNH2SSTR1SSTR3 | |
| SCHEMBL4594449 | 0.87 | SSTR5 (0.36) | SSTR5KCNH2SSTR1SSTR3SLC6A2 | |
| SCHEMBL4593947 | 0.87 | SSTR5 (0.35) | SSTR5KCNH2SSTR1SSTR3GRK5 | |
| SCHEMBL4593265 | 0.85 | SSTR5 (0.40) | SSTR5KCNH2SSTR1SSTR3SLC6A2 | |
| SCHEMBL4595027 | 0.85 | SSTR5 (0.47) | SSTR5KCNH2SSTR1 | |
| SCHEMBL4594566 | 0.85 | HTR2A (0.35) | SSTR5KCNH2SSTR1SSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |