Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594604 | 0.93 | SSTR5 (0.54) | SSTR5KCNH2SSTR1PTGDR2NPC1 | |
| SCHEMBL1380236 | 0.93 | SSTR5 (0.54) | SSTR5KCNH2SSTR1HDAC6PTGDR2 | |
| SCHEMBL4594514 | 0.92 | SSTR5 (0.46) | SSTR5KCNH2SSTR1HDAC6PTGDR2 | |
| SCHEMBL4593872 | 0.92 | SSTR5 (0.54) | SSTR5KCNH2SSTR1HDAC6PTGDR2 | |
| SCHEMBL4595027 | 0.91 | SSTR5 (0.47) | SSTR5KCNH2SSTR1 | |
| SCHEMBL4594591 | 0.89 | GAA (0.42) | SSTR5KCNH2PTGDR2HPSE | |
| SCHEMBL4594138 | 0.88 | SSTR5 (0.44) | SSTR5KCNH2SSTR1HDAC6HPSE | |
| SCHEMBL4594820 | 0.88 | SSTR5 (0.39) | SSTR5KCNH2PTGDR2POLBTDP1 | |
| SCHEMBL4593627 | 0.87 | SSTR5 (0.39) | SSTR5KCNH2SSTR1PTGDR2 | |
| SCHEMBL4594452 | 0.86 | SSTR5 (0.41) | SSTR5KCNH2SSTR1HDAC6PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |