Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 19/20 | 1.00 |
| ▸ | CYP11B1 | P15538 | 18/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175800 | 0.91 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4CYP19A1ADRA2B | |
| SCHEMBL10175802 | 0.87 | CYP11B2 (0.76) | CYP11B2CYP11B1CYP3A4CYP19A1ADRA2B | |
| SCHEMBL10175440 | 0.86 | CYP11B2 (0.76) | CYP11B2CYP11B1CYP3A4CYP19A1ADRA2B | |
| SCHEMBL17896683 | 0.85 | CYP11B2 (0.74) | CYP11B2CYP11B1CYP3A4CYP19A1ADRA2B | |
| SCHEMBL17896731 | 0.84 | CYP11B1 (0.72) | CYP11B2CYP11B1CYP3A4CYP19A1ADRA2B | |
| SCHEMBL31411949 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4CYP19A1 | |
| SCHEMBL20337629 | 0.83 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4CYP19A1 | |
| SCHEMBL10175597 | 0.82 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4CYP19A1 | |
| SCHEMBL20338266 | 0.82 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4 | |
| SCHEMBL10175803 | 0.82 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP3A4CYP19A1ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118026996-A | Preparation method of 1-cyclopropyl-5, 6-difluoro-2- (5-fluoro-4-methylpyridine-3-yl) -1H-benzo [ d ] imidazole | 无锡捷化医药科技有限公司 | 2024-05-14 | — | — | CN | claimed |
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | claimed |
| CN-118026996-A | Preparation method of 1-cyclopropyl-5, 6-difluoro-2- (5-fluoro-4-methylpyridine-3-yl) -1H-benzo [ d ] imidazole | 无锡捷化医药科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-118026996-A | Preparation method of 1-cyclopropyl-5, 6-difluoro-2- (5-fluoro-4-methylpyridine-3-yl) -1H-benzo [ d ] imidazole | 无锡捷化医药科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-118026996-A | Preparation method of 1-cyclopropyl-5, 6-difluoro-2- (5-fluoro-4-methylpyridine-3-yl) -1H-benzo [ d ] imidazole | 无锡捷化医药科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |