Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594225 | 0.93 | SSTR5 (0.40) | SSTR5HDAC6NPC1RAB9AALOX15 | |
| SCHEMBL4594278 | 0.92 | MAPT (0.46) | SSTR5HDAC6NPC1RAB9AREN | |
| SCHEMBL4594243 | 0.90 | REN (0.41) | SSTR5HDAC6NPC1RAB9AREN | |
| SCHEMBL4594247 | 0.89 | SSTR5 (0.39) | SSTR5HDAC6NPC1RAB9AALOX15 | |
| SCHEMBL4594636 | 0.85 | MAPT (0.46) | SSTR5HDAC6NPC1RAB9AREN | |
| SCHEMBL4594626 | 0.84 | SSTR5 (0.40) | SSTR5HDAC6NPC1RAB9AMAPT | |
| SCHEMBL4594255 | 0.84 | SSTR5 (0.39) | SSTR5NPC1RAB9AMAPTTP53 | |
| SCHEMBL4593368 | 0.84 | SSTR5 (0.48) | SSTR5MAPTTP53LMNA | |
| SCHEMBL4594422 | 0.83 | REN (0.42) | SSTR5HDAC6NPC1RAB9AREN | |
| SCHEMBL4594089 | 0.82 | SSTR5 (0.39) | SSTR5NPC1RAB9AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | claimed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | claimed |
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |