Carbamazepine

Carbamazepine

SCHEMBL4593916

CC(=O)O.NC(=O)N1c2ccccc2C=Cc2ccccc21

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Carbamazepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SCN4A known ✓ P35499 1/20 0.85
SCN5A known ✓ Q14524 1/20 0.85
SCN9A known ✓ Q15858 1/20 0.85
LMNA P02545 1/20 0.85
TSHR P16473 1/20 0.85
MAPK1 P28482 1/20 0.85
P2RX4 Q99571 16/20 0.66
P2RX1 P51575 4/20 0.54
P2RX3 P56373 4/20 0.54
P2RX7 Q99572 2/20 0.54
MTNR1A P48039 1/20 0.53
MTNR1B P49286 1/20 0.53
PTBP1 P26599 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
BCHE P06276 1/20 0.50
ACHE P22303 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Carbamazepine SCHEMBL28220906 0.92 LMNA (0.92) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL6477112 0.92 LMNA (1.00) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL29433237 0.92 LMNA (1.00) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL21639 0.92 LMNA (1.00) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL31685158 0.92 LMNA (1.00) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL29360181 0.92 LMNA (1.00) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL1421962 0.90 LMNA (0.96) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL5382102 0.90 LMNA (0.96) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL29390487 0.90 LMNA (0.96) LMNATSHRMAPK1SCN4ASCN5A
Carbamazepine SCHEMBL29023618 0.90 LMNA (0.96) LMNATSHRMAPK1SCN4ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004195-A1 USE OF 5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE DERIVATIVES IN THE TREATMENT OF NEUROPATHIC PAIN AND NEUROLOGICAL DISORDERS BIAL - Portela & Ca., S.A. (PT) 2008-12-24 EP claimed
WO-2007094694-A1 USE OF 5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE DERIVATIVES IN THE TREATMENT OF NEUROPATHIC PAIN AND NEUROLOGICAL DISORDERS BIAL PORTELA & C.A., S.A. (PT) 2007-08-23 WO claimed
US-20190169130-A1 MULTIPLE-COMPONENT SOLID PHASES CONTAINING AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT UNIVERSITY OF SOUTH FLORIDA 2019-06-06 US disclosed
CN-103415286-A Compounds and methods for treating pain AKRON MOLECULES GMBH 2013-11-27 CN disclosed
EP-2004195-A1 USE OF 5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE DERIVATIVES IN THE TREATMENT OF NEUROPATHIC PAIN AND NEUROLOGICAL DISORDERS BIAL - Portela & Ca., S.A. (PT) 2008-12-24 EP disclosed
WO-2007094694-A1 USE OF 5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE DERIVATIVES IN THE TREATMENT OF NEUROPATHIC PAIN AND NEUROLOGICAL DISORDERS BIAL PORTELA & C.A., S.A. (PT) 2007-08-23 WO disclosed
CN-1153475-A Carbamazepine medicament with retarded active substance release DRESDEN ARZNEIMITTEL (DE) 1997-07-02 CN disclosed