Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378262 | 0.83 | JAK2 (0.70) | JAK2HDAC1HDAC6JAK3MAP3K5 | |
| SCHEMBL13588617 | 0.81 | JAK2 (0.65) | JAK2HDAC1HDAC6JAK3MAP3K5 | |
| SCHEMBL4377247 | 0.77 | ATM (0.55) | JAK2HDAC1HDAC6JAK3MAP3K5 | |
| SCHEMBL4380161 | 0.77 | JAK2 (0.61) | JAK2HDAC1HDAC6JAK3MAP3K5 | |
| SCHEMBL4379855 | 0.76 | JAK2 (0.59) | JAK2HDAC1HDAC6JAK3MAP3K5 | |
| SCHEMBL8239261 | 0.76 | JAK2 (0.53) | JAK2HDAC1HDAC6JAK3MAP3K5 | |
| SCHEMBL4381621 | 0.73 | JAK2 (0.69) | JAK2HDAC1HDAC6MAP3K5AURKA | |
| SCHEMBL4383459 | 0.70 | JAK2 (0.82) | JAK2HDAC1HDAC6JAK3 | |
| SCHEMBL13588620 | 0.70 | JAK2 (0.61) | JAK2HDAC1HDAC6MAP3K5AURKA | |
| SCHEMBL3752960 | 0.69 | JAK2 (0.56) | JAK2HDAC1HDAC6JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |